Chapter 495： : The minecart was robbed and arrived at Bosbon (1/2)

[This chapter is the third chapter]

I know that there is a software developer conference, have you heard of a biological developer conference? Since yesterday, the world's first biodeveloper conference was held in Shanghai.

The theme of this year's conference is ”Link Opening”, which aims to promote the linkage of various communities in the entire engineering biology industry, cultivate a better ecological environment, promote the development of biotechnology products, and open a new link in the engineering biology ecosystem. Experts gathered at the conference, as well as representatives from over a hundred companies and many investors.

Using DNA as the code, professional biological developers are here

Synthetic biology is a new cross-science in the 21st century. It can use Escherichia coli to produce bulk chemical materials and get rid of the constraints of petroleum raw materials. Yeast produces artemisinic acid and rare ginsenosides to reduce costs and promote the development of new drugs; engineering bacteria do not ”Injury” normal cells and specifically attack cancer cells...

”In the era of'convergence', the research and development capabilities of life sciences and biotechnology are in urgent need of improvement.” Academician Zhao Guoping of the Chinese Academy of Sciences said at the conference. Synthetic biology uses the “bottom-up” concept of engineering to break the boundaries between “natural” and “unnatural”, from systematically characterizing natural biological macromolecules with functions such as catalytic regulation, making them standardized “elements”, to Create new biological components such as ”modules” and ”circuits” and cell ”chasses” to build artificial life systems with various uses.

Just as there are software engineers who write codes in the IT industry, biological developers are people who use DNA as the ”code” and focus on the innovation of the source of biotechnology and the development of new products. The initiator of the conference, Guo Haotian, the founder of Red Panda Bio (Shenzhen Xunzhu Biotechnology Co., Ltd.), said that in recent years, the division of labor in the biotechnology industry has become more and more detailed, and an intermediate group has appeared in the chain of the biotechnology industry. It does not study basic mechanisms, nor is it engaged in clinical trials or scale-up production, but specializes in the development of strains of fermented products, the reconstruction of chassis microorganisms, the design of protein drugs, and even molecular breeding and organoid transformation. The industry refers to this group of people as biological developers.

Provided by Wenhui, the picture point ”sugar” becomes gold, and biological development has many magical uses

What's the use of biological developers? Zhao Xinyan, Chairman of Finca Technology, cited the rapid growth of the perfume industry in recent years as an example. Sandalwood is a precious fragrance extracted from the sandalwood tree. The price of sandalwood can reach 2,000 US dollars per kilogram. A technology of biosynthesis of sandalwood from sugar can reduce the price to 2,000 yuan per kilogram. In addition to lowering prices, biosynthetic technology can also greatly reduce the plant cultivation cycle and improve safety. A kind of spice extract that needs to be planted in 150,000 mu of flower fields for one year, using a biosynthetic method, only needs to be synthesized in a petri dish for 5 days to obtain.

Fenkai Technology is researching the method of artificially synthesizing the ”king of spices”-Ambergris, which is a fixative with ”subtle velvety softness”. Zhao Xinyan said that if there is no such substance in the perfume, the fragrance will stay for up to 40 minutes, and the fragrance will stay for more than 4 hours if added. Therefore, almost all high-end perfumes are added with ambre.

At present, the company has completed the mass production of sclareol-sclareolide, and it is urgently needed to develop the next step of synthesis technology.

The conference also held a sustainable development challenge, that is, by providing a variety of biological solutions to release biological potential to promote the sustainable development of various fields. Teams from Tsinghua University, East China University of Science and Technology, Jiangnan University, ShanghaiTech University and other universities participated in the on-site competition.

Provide basic ”computing power” for life sciences

Just like IT workers need computing power, biological developers also need high-throughput, low-cost ”development tools”. The emergence of the ultra-high-throughput carrier test platform Red Panda has solved the troubles of many biological developers.

”We have encountered many such scenarios in the past. On the one hand, developers working in the front line of the laboratory did not realize that there are already good tools on the market to help them speed up research and development, reduce costs, and reduce repetitive labor; on the other hand, On the one hand, it is difficult for organizations with platform capabilities to reach customers, and they often need to spend a lot of cost to promote.” Guo Haotian said that Red Panda Bio can provide a cloud laboratory service for million-level protein recombination, which is better than international general tools. It is 6 orders of magnitude higher, and the cost is only one percent of that of ordinary tools.

The reason for achieving such a ”cost-effective ratio” stems from the fact that Red Panda Biology is based on synthetic biology cell programming technology. This is a brand new experimental method. Simply put, it is to provide bacteria with a piece of DNA code so that they can be in the cell. Work autonomously.

As a Shenzhen startup, why come to Shanghai for a meeting? Guo Haotian admitted frankly that he has taken a fancy to Shanghai and the Yangtze River Delta's high-quality biomedical resources. As a ”basic computing power” in life sciences, this tool can be linked to almost all biological industries and provide high-quality services for them.

”Ukawa Floating” talked about several points, but there was a problem with the connection. If we look at it from the perspective of the protagonist, what can we see? The protagonist returned to his hometown because he didn't have much time. Pneumoconiosis is an embarrassing disease. For many people in China, this is undoubtedly sentenced to death. After the protagonist with a painful illness returns to his hometown, what kind of life test he has to face, in the face of all kinds of hardships, how to show his feelings after illness, this is the first core theme that the author wants to tell everyone , Caring for pneumoconiosis, or starting to pay attention to a certain group that has been neglected.

When the protagonist returns to his hometown, his mother’s experience is lingering like a nightmare. The only thing that can comfort his soul is to do something silently, to erect a monument for his mother, and silently do whatever he can think of. . This is a kind of repentance for the mother's long-standing debt.

For his own brother, no matter what happened before, the first thing he thought of when he was still alive was reconciliation, reconciliation with his brother, excuses from his past, and bid farewell to his future. And meet your enemies. The scene with red eyes did not happen, and he even stopped all those who wanted to help. The stimulating scene was replaced by plainness, and everything was over. What is the point of mentioning these grievances for a dying person?

The second core point lies in the relationship between people. The protagonist’s wife divorced himself, the protagonist’s brother is at odds with him, and friends are still friends, but they all have their own lives. Even if they are enemies, the protagonist does not. Willing to look at all this with a vengeful eye, life is still going on, everyone is going on, but many people who have had intersections with them before, have lost contact at this moment, no one wants to mention the past, and no one Willing to go completely out of a certain thing. Therefore, everything becomes very awkward, and the protagonist wants to find something out of it, but in the end finds nowhere to start.

The origin of Thousand Island Lake and the influence of the changes of the times on people appear in this film imperceptibly, but this imperceptibility has not become the driving force leading the film forward. Most of the time, there is not much intersection between these elements and the film. ,This is where the problem lies. Many times we have expectations. Our expectations for a film, especially a literary film, require the creator to express it. The expression of this film is divided into several aspects, but these several aspects are single independent individuals. How these independent individuals are well connected through the protagonist, the tragic character, is the key to testing the creator’s original intention. If you can't handle this well, then no matter how good a film is, it will at best become an independent segment, but the film needs to be coherent.

In addition to self-expression, how many core domestic literary films have?

2021-10-1009:27 People's Information of the Pearl

The second core point lies in the relationship between people. The protagonist’s wife divorced himself, the protagonist’s brother is at odds with him, and friends are still friends, but they all have their own lives. Even if they are enemies, the protagonist does not. Willing to look at all this with a vengeful eye, life is still going on, everyone is going on, but many people who have had intersections with them before, have lost contact at this moment, no one wants to mention the past, and no one Willing to go completely out of a certain thing. Therefore, everything becomes very awkward, and the protagonist wants to find something out of it, but in the end finds nowhere to start.

The origin of Thousand Island Lake and the influence of the changes of the times on people appear in this film imperceptibly, but this imperceptibility has not become the driving force leading the film forward. Most of the time, there is not much intersection between these elements and the film. ,This is where the problem lies. Many times we have expectations. Our expectations for a film, especially a literary film, require the creator to express it. The expression of this film is divided into several aspects, but these several aspects are single independent individuals. How these independent individuals are well connected through the protagonist, the tragic character, is the key to testing the creator’s original intention. If you can't handle this well, then no matter how good a film is, it will at best become an independent segment, but the film needs to be coherent.

Domestic literary film directors are very accustomed to self-expression, but they always ignore the continuity of the story. Even the obscure and sophisticated literary films should have a theme to connect, otherwise no matter how good the clips are, they can only be fragments, exquisite. The five senses lack a thread, which is embarrassing.

Is ”Sugar-Free” really sugar-free?

According to the test, all milk teas called ”sugar-free” were found to contain sugar, even higher than some samples with normal sweetness.

According to a test conducted by the Shanghai Consumer Rights Protection Committee, among 27 milk tea samples with normal sweetness, the sugar content was 11-62 g/cup, and the average sugar content was 34 g per cup, with the highest milk tea. The sugar content is equivalent to 14 cubes of sugar.

Among the so-called ”less sugar”, ”low sugar”, ”de-sugar” or ”sugar-free” milk teas, all 20 of them have sugars measured, with an average sugar content of 2.4g/100ml, and a minimum of 1.2g/100ml.

”Healthy China Action (2019-2030 advocates that the average daily added sugar intake per capita is no more than 25 grams. Other countries have similar suggestions:

TheAmericanHeart;suggeststhatmenconsumenomorethan150calories(about9teaspoonsor36grams)ofaddedsugarperday.Forwomen,thenumberislower:6teaspoons(25gramsor100calories)perday.

The American Heart Association recommends that men consume no more than 150 calories of added sugar per day (about 9 teaspoons or 36 grams). For women, this number is even lower: 6 teaspoons (25 grams or 100 calories) per day.

Too much sugar is very harmful to the body. In a 2014 study published in the Journal of Internal Medicine of the American Medical Association, there was an association between a high-sugar diet and a high risk of heart disease.