Chapter 467 (1/2)

Hughes Medical Research Institute, one of the most famous non-profit medical research institutes in the United States, has become an ”angel team” Research Institute for VFV specific drugs under the coordination of who.

Qiu wants to lead the group towards the meeting room.

Qiu Xiang now has a report on the study of VFV antibody, but the faces of all the people are not very happy.

The antibody in the patient's serum or body fluid is the most common way to treat virus infection. During this period of time, their team found that the antibody in the patient's serum was too weak to remove the VFV virus at all.

And they can not find patients in recovery period. VFV virus is too toxic. The antibody produced by the immune system of human body can not ”kill” the virus at all.

As a result, their research on specific drugs was at a loss.

After discussion, the team decided to try animal immune serum, find 8 kinds of animals to experiment, let the animals infected with the virus, but soon found that even after the immunization of bovine serum, there is no obvious effect on the treatment of VFV.

During this period, I experimented every day, trying hundreds of possible ways.

Try all the possible conjectures they discussed, and finally find that the most successful one is monoclonal antibody.

In order to speed up the research, the 72 person team is divided into eight groups, four groups are responsible for finding other therapeutic drugs, the other four groups are responsible for testing the 16 monoclonal antibodies that have been developed. The team led by Qiu Xiang is one of them.

At the time of the test, the four groups all used 1000 times LD50 (half lethal dose) to infect the experimental mice.

Within 24 hours after exposure, mice were injected with monoclonal antibodies, 16 monoclonal antibodies in four groups, 11 of which were effective; 5 of which were still effective in 48 hours; and only two of them were effective in 72 hours.

It's an antibody from the first group he led, and an antibody from the third group led by Judson, a British medical scientist.

After finding two kinds of antibodies, they began to experiment with rabbits again, 24 hours later, both of them were effective; 48 hours later, the ability of monoclonal antibodies began to show obvious differences, many of them lost their activity, and the effect of antibodies became weaker and weaker after a long time.

The incubation period of VFV virus is far longer than this time. Such antibodies can not be used for treatment at all, and the research stops again.

Finally, after the discussion, we decided to use the ”cocktail” method of Ebor specific drug research, using the best four monoclonal antibodies to mix, using a virus that can produce human interferon as the adjuvant of ”cocktail” antibody, so that the ”cocktail” can play a role 72 hours after exposure.

The cocktail potion was named ag72 by them.

Now, the ag72 test results are in the hands of Qiu Xiang.

Looking at the report in hand, he was not happy because the result was different from what they imagined.

When Qiu Xiang and Judson enter the conference room, they feel dozens of eyes falling on them. Many researchers on the field don't look very good. Since the formation of the 72 person team, their research has made some progress, but the progress is not great. Now I hope all of them are on the reports in the hands of Qiu Xiang and Jason.

”Come on.” Qiu wants to pass the report to Jason.

”You come.” Judson shook his head and didn't reach for it.

Qiu thought he could not help nodding. When all the people were seated, he asked his assistant to send the report to every researcher on the field, and walked up to the podium.

”The monoclonal antibody test results are out, which is different from our prediction. We tested the effect of ag72 with two rhesus monkeys. On the fourth day of infection, the monkeys developed symptoms and were given ag72 as planned. But unfortunately, the virus in monkeys has not disappeared, and VFV has not been cured. ” Qiu Xiang's voice is heavy.