Part 15 (1/2)

[214] Schmidt's Jahrbucher, vol. 192, p. 131. 1881.--Walsh, J. Report of a Case of Poisoning by Chloride of Barium.

Lancet, vol. 1, p. 211. 1859.--Walch. Seltener Fall einer todlich. Vergiftung d. Baryta muriatica. Zeits. f.

Staatsarznk., vol. 30, p. 1. 1835.--Carpenter, J. S. Barium Chloride from a Clinical Standpoint. Med. News, vol. 59, p.

93. 1891.--Eschricht. Ddeligt forlbende Forgiftning med salpetersurt Baryt. Ugeskrift for Laeger, vol. 4, p. 241.

1881.--Ogler and Socquet. Empoisonnement par le Chlorure de Baryum. Annal. d'Hyg. Publ., 3 s., vol. 25, p. 447.

1891.--Chevallier, A. Note sur un Cas d'Empoisonnement Determine par l'Acetate de Baryte. Annal. d'Hyg. Publ., 2 s., vol. 39, p. 395. 1873.--Courtin, Cas d'Empoisonnement par du Chlorure de Baryum. Rev. d'Hyg., vol. 4, p. 653.

1882.--Poisoning by a Baryta Compound. Pharm. Journ., 3 s., vol. 2, p. 1021. 1872.--Reichardt, E. Vergiftungsfall mit kohlensaurem Baryt. Arch. d. Pharm., 3 s., vol. 4, p. 426.

1874.--Lagarde, P. Acetate de Baryte livre sous le Nom de Sulfovinate de Soude. Union Med., 3 s., vol. 14, p. 537.

1872.--Baum. Zwei Falle von fahrla.s.siger Todtung durch saltpetersaures Baryt. Zeits. f. Medizinalbeamte, vol. 9, p.

759. 1896.--Funaro, A. Sul Veneficio per Sali di Bario.

L'Orosi, vol. 12, p. 397. 1894.

[215] Tiraboschi, A., and Taito, F. Avvelenamento da Bario.

Il Risveglio Medico d'Abruzzo e Molise, vol. 1, p. 171. 1906.

NOTE.--A criticism of this case is to be found in Bellisari, G., Su Di un Presunto Avvelenamento da Bario. Il Risveglio Medico d'Abbruzzo e Molise, vol. 2, p. 15. 1907.

[216] Lopes, A. Caso Curioso de Envenenamento Pelo Chloret de Bario. Medicina Contempt., Lisbon, vol. 4, p. 109. 1886.

[217] Stern, E. Vergiftung mit Chlorbarium. Zeits. f.

Medizinalbeamte, vol. 9, p. 383. 1896.

NOTE.--The writer has always theoretically questioned the danger of poisoning by loco weeds in well-fed and well-watered animals. Compare Stalker, M., The ”Loco” Plant and Its Effect on Animals. Bur. Animal Industry, 3d Ann.

Report (1886), p. 271. 1887.

[218] Lisfranc. Lecon sur l'Emploi du Muriate de Baryte contre les Tumeurs Blanches. Gaz. Med. de Paris, 2 s., vol.

4, p. 215. 1836.

[219] Pauli, W., and Frohlich, A. Pharmakodynam. Studien.

Sitz. Kaiserl. Acad. d. Wissens. z. Wien, vol. 115, III, pt.

6, p. 445. 1906.

=PATHOLOGICAL LESIONS IN EXPERIMENTAL BARIUM POISONING.=

The post-mortem examinations in cases of acute experimental barium poisoning, according to Schedel,[220] show punctiform or large hemorrhagic effusion in the fundus ventriculi[221] and in the large and small intestines, contraction of the bladder, and hemorrhage into the walls of the bladder and uterus. The heart is usually found relaxed or the left ventricle contracted in systole, while the right is relaxed.

Only once were ecchymoses under the endocardium seen. The liver and kidneys showed nothing special. The urine was free from alb.u.men and sugar. In a few cases the lungs showed some infiltration with blood. In chronic cases, according to our own investigations in rabbits, there are no characteristic macroscopic lesions, a result which agrees with Mittelstaedt's report.[222] Nothnagel and Rossbach[223] claim that in chronic poisoning by barium the peripheral nerves are altered. The same negative results have also been reported in chronic poisoning in higher animals. Reynolds[224] noted a layer like a blood clot under the cerebellum in a horse fed with barium chlorid. Fuchs[225] has called attention to the fact that the flesh of cattle poisoned with barium chlorid was harmless, perhaps owing to a conversion into an insoluble salt, a fact which may be considered in the use of locoed animals for food.

FOOTNOTES:

[220] Schedel, H. Beitr. z. Kennt. d. Wirkung des Chlorbariums. 1903, p. 13.

[221] After subcutaneous injection of barium chlorid, Lewin, by means of the spectroscope, has found barium in the stomach walls. Lewin, L. Schicksal korperfremder chem. Stoffe im Menschen u. besonders ihre Ausscheidung. Deutsch. Med. Woch., vol. 32, p. 173. 1906.