Volume IV Part 14 (1/2)

Of course this new movement has not been confined to Germany. Indeed, it had long had exponents elsewhere. Thus in England, a full century earlier, Dr. Hartley had championed the theory of the close and indissoluble dependence of the mind upon the brain, and formulated a famous vibration theory of a.s.sociation that still merits careful consideration. Then, too, in France, at the beginning of the century, there was Dr. Cabanis with his tangible, if crudely phrased, doctrine that the brain digests impressions and secretes thought as the stomach digests food and the liver secretes bile. Moreover, Herbert Spencer's Principles of Psychology, with its avowed co-ordination of mind and body and its vitalizing theory of evolution, appeared in 1855, half a decade before the work of Fechner. But these influences, though of vast educational value, were theoretical rather than demonstrative, and the fact remains that the experimental work which first attempted to gauge mental operations by physical principles was mainly done in Germany.

Wundt's Physiological Psychology, with its full preliminary descriptions of the anatomy of the nervous system, gave tangible expression to the growth of the new movement in 1874; and four years later, with the opening of his laboratory of physiological psychology at the University of Leipzig, the new psychology may be said to have gained a permanent foothold and to have forced itself into official recognition. From then on its conquest of the world was but a matter of time.

It should be noted, however, that there is one other method of strictly experimental examination of the mental field, latterly much in vogue, which had a different origin. This is the scientific investigation of the phenomena of hypnotism. This subject was rescued from the hands of charlatans, rechristened, and subjected to accurate investigation by Dr. James Braid, of Manchester, as early as 1841. But his results, after attracting momentary attention, fell from view, and, despite desultory efforts, the subject was not again accorded a general hearing from the scientific world until 1878, when Dr. Charcot took it up at the Salpetriere, in Paris, followed soon afterwards by Dr. Rudolf Heidenhain, of Breslau, and a host of other experimenters. The value of the method in the study of mental states was soon apparent. Most of Braid's experiments were repeated, and in the main his results were confirmed. His explanation of hypnotism, or artificial somnambulism, as a self-induced state, independent of any occult or supersensible influence, soon gained general credence. His belief that the initial stages are due to fatigue of nervous centres, usually from excessive stimulation, has not been supplanted, though supplemented by notions growing out of the new knowledge as to subconscious mentality in general, and the inhibitory influence of one centre over another in the central nervous mechanism.

THE BRAIN AS THE ORGAN OF MIND

These studies of the psychologists and pathologists bring the relations of mind and body into sharp relief. But even more definite in this regard was the work of the brain physiologists. Chief of these, during the middle period of the century, was the man who is sometimes spoken of as the ”father of brain physiology,” Marie Jean Pierre Flourens, of the Jardin des Plantes of Paris, the pupil and worthy successor of Magendie.

His experiments in nerve physiology were begun in the first quarter of the century, but his local experiments upon the brain itself were not culminated until about 1842. At this time the old dispute over phrenology had broken out afresh, and the studies of Flourens were aimed, in part at least, at the strictly scientific investigation of this troublesome topic.

In the course of these studies Flourens discovered that in the medulla oblongata, the part of the brain which connects that organ with the spinal cord, there is a centre of minute size which cannot be injured in the least without causing the instant death of the animal operated upon.

It may be added that it is this spot which is reached by the needle of the garroter in Spanish executions, and that the same centre also is destroyed when a criminal is ”successfully” hanged, this time by the forced intrusion of a process of the second cervical vertebra. Flourens named this spot the ”vital knot.” Its extreme importance, as is now understood, is due to the fact that it is the centre of nerves that supply the heart; but this simple explanation, annulling the conception of a specific ”life centre,” was not at once apparent.

Other experiments of Flourens seemed to show that the cerebellum is the seat of the centres that co-ordinate muscular activities, and that the higher intellectual faculties are relegated to the cerebrum. But beyond this, as regards localization, experiment faltered. Negative results, as regards specific faculties, were obtained from all localized irritations of the cerebrum, and Flourens was forced to conclude that the cerebral lobe, while being undoubtedly the seat of higher intellection, performs its functions with its entire structure. This conclusion, which incidentally gave a quietus to phrenology, was accepted generally, and became the stock doctrine of cerebral physiology for a generation.

It will be seen, however, that these studies of Flourens had a double bearing. They denied localization of cerebral functions, but they demonstrated the localization of certain nervous processes in other portions of the brain. On the whole, then, they spoke positively for the principle of localization of function in the brain, for which a certain number of students contended; while their evidence against cerebral localization was only negative. There was here and there an observer who felt that this negative testimony was not conclusive. In particular, the German anatomist Meynert, who had studied the disposition of nerve tracts in the cerebrum, was led to believe that the anterior portions of the cerebrum must have motor functions in preponderance; the posterior positions, sensory functions. Somewhat similar conclusions were reached also by Dr. Hughlings-Jackson, in England, from his studies of epilepsy.

But no positive evidence was forthcoming until 1861, when Dr. Paul Broca brought before the Academy of Medicine in Paris a case of brain lesion which he regarded as having most important bearings on the question of cerebral localization.

The case was that of a patient at the Bicetre, who for twenty years had been deprived of the power of speech, seemingly through loss of memory of words. In 1861 this patient died, and an autopsy revealed that a certain convolution of the left frontal lobe of his cerebrum had been totally destroyed by disease, the remainder of his brain being intact.

Broca felt that this observation pointed strongly to a localization of the memory of words in a definite area of the brain. Moreover, it transpired that the case was not without precedent. As long ago as 1825 Dr. Boillard had been led, through pathological studies, to locate definitely a centre for the articulation of words in the frontal lobe, and here and there other observers had made tentatives in the same direction. Boillard had even followed the matter up with pertinacity, but the world was not ready to listen to him. Now, however, in the half-decade that followed Broca's announcements, interest rose to fever-beat, and through the efforts of Broca, Boillard, and numerous others it was proved that a veritable centre having a strange domination over the memory of articulate words has its seat in the third convolution of the frontal lobe of the cerebrum, usually in the left hemisphere. That part of the brain has since been known to the English-speaking world as the convolution of Broca, a name which, strangely enough, the discoverer's compatriots have been slow to accept.

This discovery very naturally reopened the entire subject of brain localization. It was but a short step to the inference that there must be other definite centres worth the seeking, and various observers set about searching for them. In 1867 a clew was gained by Eckhard, who, repeating a forgotten experiment by Haller and Zinn of the previous century, removed portions of the brain cortex of animals, with the result of producing convulsions. But the really vital departure was made in 1870 by the German investigators Fritsch and Hitzig, who, by stimulating definite areas of the cortex of animals with a galvanic current, produced contraction of definite sets of muscles of the opposite side of the body. These most important experiments, received at first with incredulity, were repeated and extended in 1873 by Dr. David Ferrier, of London, and soon afterwards by a small army of independent workers everywhere, prominent among whom were Franck and Pitres in France, Munck and Goltz in Germany, and Horsley and Schafer in England.

The detailed results, naturally enough, were not at first all in harmony. Some observers, as Goltz, even denied the validity of the conclusions in toto. But a consensus of opinion, based on mult.i.tudes of experiments, soon placed the broad general facts for which Fritsch and Hitzig contended beyond controversy. It was found, indeed, that the cerebral centres of motor activities have not quite the finality at first ascribed to them by some observers, since it may often happen that after the destruction of a centre, with attending loss of function, there may be a gradual restoration of the lost function, proving that other centres have acquired the capacity to take the place of the one destroyed. There are limits to this capacity for subst.i.tution, however, and with this qualification the definiteness of the localization of motor functions in the cerebral cortex has become an accepted part of brain physiology.

Nor is such localization confined to motor centres. Later experiments, particularly of Ferrier and of Munck, proved that the centres of vision are equally restricted in their location, this time in the posterior lobes of the brain, and that hearing has likewise its local habitation.

Indeed, there is every reason to believe that each form of primary sensation is based on impressions which mainly come to a definitely localized goal in the brain. But all this, be it understood, has no reference to the higher forms of intellection. All experiment has proved futile to localize these functions, except indeed to the extent of corroborating the familiar fact of their dependence upon the brain, and, somewhat problematically, upon the anterior lobes of the cerebrum in particular. But this is precisely what should be expected, for the clearer insight into the nature of mental processes makes it plain that in the main these alleged ”faculties” are not in themselves localized.

Thus, for example, the ”faculty” of language is a.s.sociated irrevocably with centres of vision, of hearing, and of muscular activity, to go no further, and only becomes possible through the a.s.sociation of these widely separated centres. The destruction of Broca's centre, as was early discovered, does not altogether deprive a patient of his knowledge of language. He may be totally unable to speak (though as to this there are all degrees of variation), and yet may comprehend what is said to him, and be able to read, think, and even write correctly. Thus it appears that Broca's centre is peculiarly bound up with the capacity for articulate speech, but is far enough from being the seat of the faculty of language in its entirety.

In a similar way, most of the supposed isolated ”faculties” of higher intellection appear, upon clearer a.n.a.lysis, as complex aggregations of primary sensations, and hence necessarily dependent upon numerous and scattered centres. Some ”faculties,” as memory and volition, may be said in a sense to be primordial endowments of every nerve cell--even of every body cell. Indeed, an ultimate a.n.a.lysis relegates all intellection, in its primordial adumbrations, to every particle of living matter. But such refinements of a.n.a.lysis, after all, cannot hide the fact that certain forms of higher intellection involve a pretty definite collocation and elaboration of special sensations. Such specialization, indeed, seems a necessary accompaniment of mental evolution. That every such specialized function has its localized centres of co-ordination, of some such significance as the demonstrated centres of articulate speech, can hardly be in doubt--though this, be it understood, is an induction, not as yet a demonstration. In other words, there is every reason to believe that numerous ”centres,” in this restricted sense, exist in the brain that have as yet eluded the investigator. Indeed, the current conception regards the entire cerebral cortex as chiefly composed of centres of ultimate co-ordination of impressions, which in their cruder form are received by more primitive nervous tissues--the basal ganglia, the cerebellum and medulla, and the spinal cord.

This, of course, is equivalent to postulating the cerebral cortex as the exclusive seat of higher intellection. This proposition, however, to which a safe induction seems to lead, is far afield from the substantiation of the old conception of brain localization, which was based on faulty psychology and equally faulty inductions from few premises. The details of Gall's system, as propounded by generations of his mostly unworthy followers, lie quite beyond the pale of scientific discussion. Yet, as I have said, a germ of truth was there--the idea of specialization of cerebral functions--and modern investigators have rescued that central conception from the phrenological rubbish heap in which its discoverer unfortunately left it buried.

THE MINUTE STRUCTURE OF THE BRAIN

The common ground of all these various lines of investigations of pathologist, anatomist, physiologist, physicist, and psychologist is, clearly, the central nervous system--the spinal cord and the brain.

The importance of these structures as the foci of nervous and mental activities has been recognized more and more with each new accretion of knowledge, and the efforts to fathom the secrets of their intimate structure has been unceasing. For the earlier students, only the crude methods of gross dissections and microscopical inspection were available. These could reveal something, but of course the inner secrets were for the keener insight of the microscopist alone. And even for him the task of investigation was far from facile, for the central nervous tissues are the most delicate and fragile, and on many accounts the most difficult of manipulation of any in the body.

Special methods, therefore, were needed for this essay, and brain histology has progressed by fitful impulses, each forward jet marking the introduction of some ingenious improvement of mechanical technique, which placed a new weapon in the hands of the investigators.

The very beginning was made in 1824 by Rolando, who first thought of cutting chemically hardened pieces of brain tissues into thin sections for microscopical examination--the basal structure upon which almost all the later advances have been conducted. Muller presently discovered that b.i.+.c.hromate of pota.s.sium in solution makes the best of fluids for the preliminary preservation and hardening of the tissues. Stilling, in 1842, perfected the method by introducing the custom of cutting a series of consecutive sections of the same tissue, in order to trace nerve tracts and establish s.p.a.cial relations. Then from time to time mechanical ingenuity added fresh details of improvement. It was found that pieces of hardened tissue of extreme delicacy can be made better subject to manipulation by being impregnated with collodion or celloidine and embedded in paraffine. Latterly it has become usual to cut sections also from fresh tissues, unchanged by chemicals, by freezing them suddenly with vaporized ether or, better, carbonic acid.

By these methods, and with the aid of perfected microtomes, the worker of recent periods avails himself of sections of brain tissues of a tenuousness which the early investigators could not approach.

But more important even than the cutting of thin sections is the process of making the different parts of the section visible, one tissue differentiated from another. The thin section, as the early workers examined it, was practically colorless, and even the crudest details of its structure were made out with extreme difficulty. Remak did, indeed, manage to discover that the brain tissue is cellular, as early as 1833, and Ehrenberg in the same year saw that it is also fibrillar, but beyond this no great advance was made until 1858, when a sudden impulse was received from a new process introduced by Gerlach. The process itself was most simple, consisting essentially of nothing more than the treatment of a microscopical section with a solution of carmine. But the result was wonderful, for when such a section was placed under the lens it no longer appeared h.o.m.ogeneous. Sprinkled through its substance were seen irregular bodies that had taken on a beautiful color, while the matrix in which they were embedded remained unstained. In a word, the central nerve cell had sprung suddenly into clear view.

A most interesting body it proved, this nerve cell, or ganglion cell, as it came to be called. It was seen to be exceedingly minute in size, requiring high powers of the microscope to make it visible. It exists in almost infinite numbers, not, however, scattered at random through the brain and spinal cord. On the contrary, it is confined to those portions of the central nervous ma.s.ses which to the naked eye appear gray in color, being altogether wanting in the white substance which makes up the chief ma.s.s of the brain. Even in the gray matter, though sometimes thickly distributed, the ganglion cells are never in actual contact one with another; they always lie embedded in intercellular tissues, which came to be known, following Virchow, as the neuroglia.

Each ganglion cell was seen to be irregular in contour, and to have jutting out from it two sets of minute fibres, one set relatively short, indefinitely numerous, and branching in every direction; the other set limited in number, sometimes even single, and starting out directly from the cell as if bent on a longer journey. The numerous filaments came to be known as protoplasmic processes; the other fibre was named, after its discoverer, the axis cylinder of Deiters. It was a natural inference, though not clearly demonstrable in the sections, that these filamentous processes are the connecting links between the different nerve cells and also the channels of communication between nerve cells and the periphery of the body. The white substance of brain and cord, apparently, is made up of such connecting fibres, thus bringing the different ganglion cells everywhere into communication one with another.

In the attempt to trace the connecting nerve tracts through this white substance by either macroscopical or microscopical methods, most important aid is given by a method originated by Waller in 1852. Earlier than that, in 1839, Na.s.se had discovered that a severed nerve cord degenerates in its peripheral portions. Waller discovered that every nerve fibre, sensory or motor, has a nerve cell to or from which it leads, which dominates its nutrition, so that it can only retain its vitality while its connection with that cell is intact. Such cells he named trophic centres. Certain cells of the anterior part of the spinal cord, for example, are the trophic centres of the spinal motor nerves.