Part 10 (2/2)

de Grey, A. D. (2002). ”Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm aging.” Eur J Biochem Eur J Biochem 269(8): 1995. 269(8): 1995.

CHAPTER 5: THE EVOLUTION OF AGING.

Peter Medawar's key essays about the evolution of aging are reprinted in: Medawar, P. (1981). The Uniqueness of the Individual The Uniqueness of the Individual. Dover.

He returns to the subject in his quirky autobiography: Medawar, P. (1988). Memoir of a Thinking Radish Memoir of a Thinking Radish. Oxford University Press.

And again in: Medawar, P. (1990). The Threat and the Glory The Threat and the Glory. HarperCollins.

See also: Finch, C. E., and E. M. Crimmins (2004). ”Inflammatory exposure and historical changes in human life-spans.” Science Science 305(5691): 173639. 305(5691): 173639.

Caspari, R., and Lee, S.-H. (2004). ”Older age becomes common late in human evolution.” PNAS PNAS 101(30): 1089510900. 101(30): 1089510900.

Crespi, B. J. (2004). ”Vicious circles: Positive feedback in major evolutionary and ecological transitions.” TREE TREE 19(12): 62733. 19(12): 62733.

Rose, M. R. (1991). Evolutionary Biology of Aging Evolutionary Biology of Aging. Oxford University Press.

Stearns, S. C., and J. C. Koella (2008). Evolution in Health and Disease Evolution in Health and Disease. Oxford University Press.

Platt, R. (1963). ”Reflections on ageing and death.” Lancet Lancet. 281: 16.

CHAPTER 6: THE GARBAGE CATASTROPHE.

Holliday, R. (2006). ”Aging is no longer an unsolved problem in biology.” Ann NY Acad Sci Ann NY Acad Sci 1067: 19. 1067: 19.

de Grey, A. D. (2007). ”Alzheimer's, atherosclerosis, and aggregates: A role for bacterial degradation.” Nutr Rev Nutr Rev 65(12 Pt 2): S22127. 65(12 Pt 2): S22127.

Terman, A., and U. T. Brunk (2006). ”Oxidative stress, acc.u.mulation of biological 'garbage,' and aging.” Antioxid Redox Signal Antioxid Redox Signal 8(12): 197204. 8(12): 197204.

Stroikin, Y., H. Dalen, et al. (2005). ”Testing the 'garbage' acc.u.mulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy.” Biogerontology Biogerontology 6(1): 3947. 6(1): 3947.

CHAPTER 7: THE SEVEN DEADLY THINGS.

For a full-length treatment of de Grey's Strategies for the Engineering of Negligible Senescence, see his book Ending Aging Ending Aging (op cit.). (op cit.).

He's also published dozens of shorter accounts, including: de Grey, A. D. (2005). ”A strategy for postponing aging indefinitely.” Stud Health Technol Inform Stud Health Technol Inform 118: 20919. 118: 20919.

For Michael Hecht's experiments with beta-amyloid: Kim, W., Y. Kim, et al. (2006). ”A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide.” ACS Chem Biol ACS Chem Biol 1(7): 46169. 1(7): 46169.

Kim, W., and M. H. Hecht (2008). ”Mutations enhance the aggregation propensity of the Alzheimer's A beta peptide.” J Mol Biol J Mol Biol 377(2): 56574. 377(2): 56574.

de Grey, A. D., P. J. Alvarez, et al. (2005). ”Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases.” Ageing Res Rev Ageing Res Rev 4(3): 31538. 4(3): 31538.

CHAPTER 8: THE METHUSELAH WARS.

For a meticulously detailed contemporary history, see Hall, S. (2003). Merchants of Immortality: Chasing the Dream of Human Life Extension Merchants of Immortality: Chasing the Dream of Human Life Extension. Houghton Mifflin.

Kla.s.s, M. R. (1983). ”A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results.” Mech Ageing Dev Mech Ageing Dev 22(34): 27986. 22(34): 27986.

Kla.s.s, M., and D. Hirsh (1976). ”Non-ageing developmental variant of Caenorhabditis elegans.” Nature Nature 260(5551): 52325. 260(5551): 52325.

Kenyon, C., J. Chang, et al. (1993). ”A C. elegans mutant that lives twice as long as wild type.” Nature Nature 366(6454): 46164. 366(6454): 46164.

Kenyon, C. (2005). ”The Plasticity of Aging: Insights from Long-Lived Mutants.” Cell Cell 120: 44960. 120: 44960.

Song, S., and T. Finkel (2007). ”GAPDH and the search for alternative energy.” Nature Cell Biology Nature Cell Biology 9(8): 86970. 9(8): 86970.

Zhang C., and A. M. Cuervo (2008). ”Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function.” Nat Med Nat Med 14(9): 95965. 14(9): 95965.

Kaus.h.i.+k S., and A. M. Cuervo (2008). ”Chaperone-mediated autophagy.” Methods Mol Biol Methods Mol Biol 445:22744. 445:22744.

Cuervo, A. M. (2008). ”Autophagy and aging: Keeping that old broom working.” Trends Genet Trends Genet 24: 60412. 24: 60412.

Cuervo, A. M., L. Stefanis, et al. (2004). ”Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy.” Science Science 305: 129295. 305: 129295.

Mizus.h.i.+ma N., B. Levine, et al. (2008). ”Autophagy fights disease through cellular self-digestion.” Nature Nature 451:106975. 451:106975.

Hansen, M., A. Chandra, et al. (2008). ”A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.” PLoS Genet PLoS Genet 4(2): e24. 4(2): e24.

Rubinsztein, D. C., J. E. Gestwicki, et al. (2007). ”Potential therapeutic applications of autophagy.” Nat Rev Drug Discov Nat Rev Drug Discov 6(4): 30412. 6(4): 30412.

Sarkar, S., E. O. Perlstein, et al. (2007). ”Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.” Nat Chem Biol Nat Chem Biol 3(6): 33138. 3(6): 33138.

Sarkar, S., B. Ravik.u.mar, et al. (2009). ”Autophagic clearance of aggregate-p.r.o.ne proteins a.s.sociated with neurodegeneration.” Methods Enzymol Methods Enzymol 453: 83110. 453: 83110.

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